Menstrual Cramps, PMS, Tylenol®, & Acetaminophen

by Dr. Daniel J. Heller December 26, 2011

The most common medication used for menstrual cramps, PMS cramps relief, and menstrual pain in general is Tylenol®, also known as acetaminophen or, in Europe, paracetamol. It is the main ingredient in the over-the-counter medications Pamprin® and Midol®, both of which are sold as PMS or menstrual pain remedies. Some of the specific brands include: Midol PMS®, Midol PMS Maximum Strength®, Pamprin Cramp Menstrual Relief®, Pamprin Max Menstrual Pain Relief®, and Pamprin Multi-Symptom Menstrual Pain Relief®. 

It has been known for decades that acetaminophen is a liver toxin, and that overdoses can lead to damage or death. Natural health practitioners usually recommend natural alternatives for PMS pain relief and natural menstrual pain remedies for just this reason. 

In fact, just as an overdose causes major damage, even ongoing low level use of acetaminophen-containing products such as Tylenol®, Pamprin®, and Midol® may be very hard on the liver. Combined with the many environmental toxins to which our bodies are subject everyday from household and industrial chemicals, car exhaust, and the like, we think natural alternatives for PMS symptom relief and menstrual cramps relief is even more important.  And you should definitely avoid taking Tylenol® or generic acetaminophen in addition to the over-the-counter drugs mentioned above, since that would be a double dose of acetaminophen.

The potential problems with acetaminophen were confirmed by a recent study published in the British Journal of Clinical Pharmacology that showed that repeated smaller overdoses of acetaminophen are more toxic than a single large overdose. This is precisely the kind of pattern that could be expected when women self-medicate for severe menstrual cramps or PMS pain relief using acetaminophen-containing products. What’s more, the longer it takes to go to the hospital once you’ve overdosed with acetaminophen, the worse the outcome. And we can easily imagine that women with PMS cramps and pain are likely to delay going to the hospital, since they feel so awful and may well think that their symptoms are a result of PMS rather than drug overdose.

This is yet another reason why natural PMS remedies such as our PMS Comfort Relief Programs and our PMS Balance Diet are so important: they help prevent and relieve symptoms without potentially toxic medications. In the process, they help you become naturally healthy and allow you to avoid overburdening your body with chemical toxins.

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The information and contents contained in this Web site has not been evaluated by the FDA. Products are not intended to diagnose, treat, cure, or prevent any disease. If you are pregnant, intend to become pregnant, or nursing, please consult a physician before taking any dietary supplement. If taking prescription drugs, consult your healthcare practitioner prior to use. You must be 18 years or older to purchase products. Individual results do vary.         

About The PMS Comfort Blog

The PMS Comfort Blog is our informal way of keeping you up to date on women’s health issues that we think are important; timely; underappreciated; useful; or just interesting. And, we’ll admit, sometimes we can’t resist poking some good-natured fun at the way the mainstream media portrays health, natural health, and women’s health issues. As always, we’d love to hear from you and are interested in knowing what you think and feel about these or other topics. Leave a comment for us, we’ll always respond. And, if there’s a women’s health topic that’s of interest to you, or that you find confusing, let us know! We want this blog to be helpful to you.


Dr. Daniel Heller is the primary author of this blog, the developer of our PMS Natural Relief Programs, and the founder of He is a holistic naturopathic doctor in Northern California with over 16 years experience helping thousands of women recover from PMS, PMDD, as well as helping women, children, and families find natural answers to all manner of health challenges.


PMS Comfort is here to support you with detailed, practical knowledge presented in a balanced manner you can trust. We are committed to educating, informing, and empowering womenregarding PMS, PMDD, and women’s health, and to providing natural relief for premenstrual symptoms.



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